Functional DNA Nanotechnology in Sensing and Imaging （Yi Lu UIUC）.pdf

Functional DNA Nanotechnology in Functional DNA Nanotechnology in Sensing and Imaging Sensing and Imaging Yi Lu Department of Chemistry, Biochemistry, Bioengineering, Materials Science and Engineering, Center for Biophysics and Computational Biology, and Beckman Institute for Advanced Science and Technology University of Illinois at Urbana-Champaign Urbana, IL 61801 Science Technology Gap in Nanobiotechnology Science Technology Gap in Nanobiotechnology Sarcosine: Prostate cancer marker in urine (Nature, 2009, 457, 910) Well developed (relatively speaking): DNA, RNA and proteins Less well developed: Carbohydrates Metabolites: metal ions: calcium, iron…. organic molecules: ATP, NADH, hormone, receptor…. (biomarkers for biological events such biomass conversion) Invasive species: metal ions: lead, mercury… organic molecules: dioxins, pesticides, PCBs, melamine.. (biomarkers for diseases such as cancer) A number of non-DNA/RNA/Protein biomarkers remain to be discovered and detected Correlation of metabolites/biomarkers with DNA/RNA/Protein levels and with biological function is an unmet challenge in nanobiotechnology. Metabolites/markers in biology and environment Metabolites/markers in biology and environment G rou p 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 P eriod • Essential Metal ions