止血灵胶囊止血缩宫抗炎的药效学研究.pdf

- 40 - Drug Evaluation Research 第 37 卷 第 1 期 2014 年 2 月 止血灵胶囊止血缩宫抗炎的药效学研究 1 1 1 1 2 潘 兰 ，王诗用 ，叶志文 ，何丹璇 ，林 军 1. 广西玉林制药集团有限责任公司，广西 玉林 537001 2. 广西医科大学，广西 南宁 530021 摘 要：目的 研究止血灵胶囊的止血、缩宫、抗炎、补血等药理作用。方法 采用相应的药理学模型研究止血灵胶囊在止 血、缩宫、抗炎、补血方面的作用。结果 止血灵胶囊对大鼠子宫平滑肌有明显的兴奋作用，显著增加大鼠子宫平滑肌收缩 幅度和活动力；能明显缩短小鼠出血时间及大鼠凝血酶时间；对大鼠血小板数和血小板聚集功能有一定的提高作用趋势；对 二甲苯致小鼠耳廓肿胀有明显的抑制作用；明显抑制小鼠腹腔毛细血管通透性增高和大鼠棉球肉芽肿的形成；对雌性失血性 “血虚”小鼠的血红蛋白含量及红细胞数目有一定的提高作用。结论 止血灵胶囊具有缩宫、止血、消炎三重功效，并有一 定补血的作用。 关键词：止血灵胶囊；收缩子宫；出血时间；凝血酶时间；抗炎；血虚 中图分类号：R965.1 文献标志码：A 文章编号：1674 - 6376 (2014) 01 - 0040 - 07 DOI: 10.7501/j.issn.1674-6376.2014.01.010 Hemostasis, anti-inflammatory, and uterine contracting effects of Zhixueling Capsule 1 1 1 1 2 PAN Lan , WANG Shi-yong , YE Zhi-wen , HE Duan-xuang , LIN Jun 1. Guangxi Yulin Pharmaceutical Group Co. Ltd., Yulin 537001, China 2. Guangxi Medical University, Nanning 530021, China Abstract: Objective To study the pharmacological effects of Zhixueling Capsule on hemostasis, uterine contraction, anti- inflammation, and enriching blood, and to explore its mechanisms. Methods Corresponding pharmacological animal models were established to investigate the uterine contraction, and hemostatic, anti-inflammatory, and blood enriching effects of Zhixueling Capsule. Results Zhixueling Capsule could excite uterine smooth muscle of rats significantly, and increase the twitch amplitude and activity of uteri in vitro. It was observed that Zhixueling Capsule could shorten the bleeding time in mice and thrombin time in rats significantly, as well as increase the platelet amount and platelet aggregation in rats. It was also observed that Zhixueling Capsule could significantly inhibit the ear edema induced by xylene and the increase of abdominal capillary permeability ind