上皮-间质转化与肝细胞癌炎症微环境的关系研究-中国循证医学杂志.pdfVIP

中国普外基础与临床杂志 2017年7月第24卷第7期 • 1 •   ·综 述· 上皮-间质转化与肝细胞癌炎症微环境的 关系研究 阎龙，戴朝六 中国医科大学附属盛京医院肝胆脾外科（沈阳  110004 ） 【摘要】   目的    分别对肝细胞癌炎症微环境和其上皮-间质转化过程进行介绍，并对二者之间的关系做一综 述。 方法     通过对国内外相关文献的查阅和筛选，对上皮-间质转化与肝细胞癌炎症微环境二者之间的关系进行 归纳和总结。 结果    肝细胞癌炎症微环境中的许多炎症因子以及病毒基因编码蛋白都在其肿瘤的上皮-间质转化 过程中扮演了重要角色，对肿瘤的侵袭转移推波助澜。 结论    肝细胞癌的炎症微环境是其上皮-间质转化过程中 不可或缺的角色，其炎症微环境的抑制和治疗可能在控制肿瘤侵袭转移方面起到更加积极的作用。 【关键词】  上皮-间质转化；肿瘤侵袭转移；肿瘤微环境；肝细胞癌；炎症因子 Study on the relationship between epithelial-mesenchymal transition and the inflammatory microenvironment of hepatocellular carcinoma YAN Long, DAI Chaoliu Department of Hepatobiliary and Splenic Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R.China Corresponding author: DAI Chaoliu, Email: daicl@sj-hospital.org 【Abstract 】 Objective    To introduce the inflammatory microenvironment and epithelial-mesenchymal transition process of hepatocellular carcinoma, and review the relationship between them. Methods    Domestic and international literatures were collected to summary the relationship between epithelial-mesenchymal transition and the inflammatory microenvironment of hepatocellular carcinoma. Result    Many inflammatory factors and viral gene encoding proteins in the inflammatory microenvironment play an important role in the process of epithelial-mesenchymal transition in hepatocellular carcinoma. Conclusions    The inflammatory microenvironment of hepatocellular carcinoma is an indispensable role in the process of epithelial-mesenchymal transition. The inhibition and treatment of inflammatory microenvironment may play a more active role in the control of tumor invasion and metastasis. 【Keywords 】 epithelial-mesenchymal transition; tumor invasion and metastasis; tumor