徐长卿内关穴位注射对大鼠心肌缺血再灌注损伤的影响-药学实践杂志.PDFVIP

212 The Jour al of Pharmaceutical Practice Vol. 18 2000 No.4 * 孙平龙, 朱晓梅, 卫洪昌( , 200032) : : 研究中药徐长卿内关穴位注射对实验性心肌缺血再 注损伤的作用及其机制: 建立心肌缺血再 注损伤动物模型,A 组动物由内关穴注入徐长卿注射液; B 组动物肌注徐长卿注 射液; C 组动物静脉注射维拉帕米; D 组动物内关穴注射生理盐水进行治疗定时测定血液动力学 指标, 实验结束时取血小板及心肌组织测定钙离子含量: 徐长卿内关穴位注射可显著升高因 缺血再 注损伤所致动脉压和左心室内压下降( P 005) ; 降低异常升高的LVEDP 和- dp / dtmax 值 (P 005) , 减轻心肌细胞内钙超载其对心肌舒张功能和钙离子作用与维拉帕米注射液相仿, 对 于心肌收缩功能作用优于其余各组: 徐长卿内关穴位注射抗心肌缺血再 注损伤的作用可 通过减轻心肌细胞内钙超载而改善心脏功能 : 徐长卿; 再 注损伤; 钙离子; 心脏血液动力学; 大鼠; 内关穴位注射 : R2827105 : A : 1006- 0111( 2000) 04- 0212- 04 Effects on myocardial ischemia re-perfusion injury treated by injection of Radix Cynanchi Panticulati (RCP)on Neiguan(PC6)acupoint in rat SUN Pi g-lo g, ZHU Xiao-mei, WEI Ho g-cha g( Chi a Sha ghai U iversity of Traditio al Chi ese Medici e a d Pharmacology,Sha ghai 200032, Chi a) ABS RAC :OBJEC IVE:To Study the effects o myocardial ischemia re- perfusio i jury treated by RCP o PC6 acupoi t i rat. ME HODS:Wistar rats were ra domized i to groups of RCP acupoi t group( A) ; i.m. RCP group( B) ; verapamil group( C) a d NS co trol group( D) . Myocardial ischemia re- perfusio i jury models were set up.The hemody amics parameters of the blood pressure( BP) , left ve tricular e d systolic pres- sure(LVESP) , left ve tricular e d diastolic pressure( LVEDP) a d dp / dt max were recorded duri g the experi- me t. The i tracelluar free calcium of the serum platelets a d myocardial cells were measured with fluoresce t probe, fura-2 established 2h after myocardial ischemia re- perfusio i jury models. RESUL S:I group A a d group C, the co ce tratio of calcium io i myocardial cell were lower tha that i group D( P 001) .Group A was higher tha group D i BP, LVESP a d was lower i LVEDP, - dp / dtmax . Differe ce of the up- me - tio ed i dexes betwee group A a d group C appeared to be i sig ifica t. CONCLUSION:PC6 acupoi t i - jectio by RCP might i crease myocardial co tractility