胃癌中CMetMMP9TIMP1的表达与浸润转移研究.pdf

护丈潇J 胃癌中C-Met,MMP-9,TIMP-1的表达与漫润转移 目的研究肝细胞生长因子受体 C-Met,墓质金属蛋白酶-9 (matrixmetalloproteinase-9,MMP-9)及其组织抑制因子一1(tissue inhibitorofmetalloproteinase-1,TIMP-1)在胃癌中的表达情况，探 讨三者的表达与胃癌侵袭转移间的关系及三者间的联系。方孩应用 免疫组化方法检测41例胃癌标本中C-Met,MMP从TIMP-1的表达， 并进行回顾性随访。份容伴有淋巴结转移或肝转移的胃癌C-Met 的阳性表达 (57.89%,75%)明显高于无转移者 (27.27%,33.33% P0.01)。侵及肌层以上者MMP-9的阳性表达 (66.67%)明显高 于肿瘤局限于粘膜、粘膜下者(20% P0.01)。NR-9阳性表达 与胃癌的淋E转移有相关性(P0.01).11MP-1的表达随胃癌侵润 深度增加而减少，当肿瘤突破浆膜时TIMP-1的表达呈现陡降趋势 (P0.01)NOW-9表达与C-Met表达呈明显正相关(P0.005)o 浩份C-Met和MW-9的过阳性表达可能与胃癌转移行为有关。 TIMP-1可能抑制胃癌的浸润转移。 关健词 胃癌;C-Met;NOW-9;TIMP-1;转移 2 圈痛中C4Aec.t‘口AW-t的表达与涯得转移 Abstract C-Met.MMP-9andTIMP-1expressionsingastric carcinomaandtheirrelationstoinvasivenessand metastasis 0匆ectiveTostudytherelationshipbetweenexpressionsofC-Met, matrix metalloproteinase-9(MMP9) and tissue inhibitor of metalloproteinase-l(TIMP-1)andtheinvasiveness,metastasisingastric carcinoma.MethodsByusingimmunohistochemisuy,detecttheexpres- sionofC-Met,MMP-9andTM-1in40gastriccarcinomas,andthe patientswerefollowed-up.ResultsThepositiveexpressionofC-Met andMMP-9ingastriccancerswithlymphnodemetastasesorliver metastaseswashigherthanthatwithoutlymphnodemetastasesorliver metastases(P0.01).TheexpressionofMW -9inthetumorinvasion beyondmusculariispropriawashigherthanthatwithinlaminapropria orsubmucosa(P0.01).TherelationoftheexpressionofTM -1tothe depthofinvasionwasnegative(P0.01).TherelationofC-Metwas positivelyrelatedtotheexpressionofMW -9.ConclusionThe expressionofC-MetandMW -9wasprobablypositivelyrelatedto metastasicbehaviorofgastriccarcinoma.TheexpressionofTIMP-1 probablyinhibitedtumormetastasis. X匀sword:Gastriccarcinoma;C-MetM;MP-9;TIAP-1;Metastases 3 赎盛啥C褶白叻0四魂不山理.L的表达毒没润瀚移