Application of multiplexed immunoglobulin E determination on a chip in component resolved diagnostics in allergy英文电子书.pdf

doi: 10.1111/j.1365-2222.2009.03402.x Clinical Experimental Allergy, 40, 190–192 EDITORIAL c 2009 Blackwell Publishing Ltd Clinical Application of multiplexed immunoglobulin E Experimental determination on a chip in component-resolved Allergy diagnostics in allergy This editorial discusses the findings in the two papers by Ebo et al. [12,13] pp. 339–47, 348–58. E. F. Knol and A. C. Knulst Department Of Dermatology/Allergology, University Medical Center Utrecht, Utrecht, The Netherlands Introduction ongoing efforts and the list of allergenic proteins is still expanding. As is nicely shown for peanut there are up to In the diagnostic evaluation of the allergic patient several now (September 2009) 10 different proteins described tests are available that can help, next to a well-taken history, with allergenic potential (Table 1). For many allergen to get better insight in the culprit allergens. The skin prick sources, purified or recombinant allergens have become test (SPT) is a quick test with high sensitivity, but can only be available to test for IgE binding. These allergens have been applied using well-char