The Role of Vitamin D in Asthmatic Children英文电子书.pdf

Curr Allergy Asthma Rep (2011) 11:1–3 DOI 10.1007/s11882-010-0151-x CLINICAL TRIAL REPORT The Role of Vitamin D in Asthmatic Children Marianne Frieri Published online: 5 October 2010 # Springer Science+Business Media, LLC 2010 Trial Methods Searing DA, Zhang Y, Murphy JR, et al.: Decreased serum Searing et al. analyzed 25-hydroxyvitamin D serum levels vitamin D levels in children with asthma are associated in 100 asthmatic children 0 to 18 years of age to examine with increased corticosteroid use. J Allergy Clin Immunol the relationship between 25-hydroxyvitamin D levels and 2010, 125:995– 1000. patient characteristics and determine vitamin D ’s in vitro effects on dexamethasone induction of mitogen-activated protein kinase phosphatase-1 and interleukin-10 in periph- Rating eral blood mononuclear cells [1, 2]. Univariate relationships between 25-hydroxyvitamin D levels and patient demo- ••Of major importance. graphic and therapeutic characteristics were determined using the Spearman rank correlation coefficient when the variables were continuous, and the Wilcoxon test with X 2 Introduction approximation when they were categorical. Statistical analysis was pe