Bupropion sustained release versus paroxetine for the treatment of depression in the elderly英文电子书.pdf

Bupropion SR vs. Paroxetine in Elderly Depressed Patients Bupropion Sustained Release Versus Paroxetine for the Treatment of Depression in the Elderly Karen L. Weihs, M.D.; Edmund C. Settle, Jr., M.D.; Sharyn R. Batey, Pharm.D.; Trisha L. Houser, B.A.; Rafe M. J. Donahue, Ph.D.; and John A. Ascher, M.D. © C Major depression is a common and potentially life- Background: Depression is a serious and wide- threatening disorder in the elderly that poses a o major public health problem.1 Depression has been asso- p spread emotional disorder among the elderly. This y study compared the efficacy and safety of bupropion ciated with more social disability than coronary artery dis- r sustained release (SR) with the selective serotonin ease, pulmonary disease, hypertension, diabetes, arthritis, i reuptake inhibitor paroxetine in the treatment of g back problems, or gastrointestinal disorders and is the third major depression in elderly outpatients. h leading cause of physical disability, behind only coronary t Method: Elderly (≥60 years) outpatients with 2 artery disease and pulmonary disease.2 Depressive symp- major depressive disorder (DSM-IV criteria) were 0 evaluated in this 6-week multicenter, randomized, toms have been estimated