The role of novel genes in modifying airway responses in asthma英文电子书.pdf

The Role of Novel Genes in Modifying Airway Responses in Asthma Hae-Sim Park, MD, PhD, Seung-Hyun Kim, PhD, and Choon-Sik Park, MD, PhD Corresponding author suggesting linkages to more than a dozen chromosomal Choon-Sik Park, MD, PhD regions and loci, which were followed by fine mapping Division of Allergy and Respiratory Medicine, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Jung Dong analysis and positional cloning. In recent years, four Wonmi Gu, Bucheon, Kyonggi Do, Korea. novel genes relating to asthma were identified, including E-mail: mdcspark@hanmail.net ADAM33 on chromosome 20p13 [4••], PHF11 on chro- Current Allergy and Asthma Reports 2006, 6: 112– 116 mosome 13q14 [5], DPP10 on chromosome 2q14 [6], and Current Science Inc. ISSN 1529-7322 GPRA on chromosome 7p15-14 [7,8]. In recent association Copyright © 2006 by Current Science Inc. studies, major associations with several candidate genes, including interleukin-4 (IL-4), IL-13, ADRB2, tumor necrosis factor-α (TNF-α), HLA-DRB1, and FcεRI were Major progress has been made during the past few years replicated with asthma-related phenotypes in more than in developing a better understanding of the genetic basis five centers [9]. Chronic airway inflammation composed of asthma, which has led to the identification of several