Oral Food Desensitization英文电子书.pdf

Curr Allergy Asthma Rep (2010) 10:391–397 DOI 10.1007/s11882-010-0142-y Oral Food Desensitization Todd D. Green A. Wesley Burks Published online: 21 August 2010 # Springer Science+Business Media, LLC 2010 Abstract The immunologic interactions in the gastroin- Introduction testinal tract are extensive and complex. In most cases, the end result of this activity is one of tolerance, which refers In recent years, the prevalence and public awareness of IgE- to the inhibition of an immune response. However, in a mediated food allergy appear to be increasing. Although up minority of cases, food allergy develops, and this seems to to 35% of individuals self-report a food allergy, studies be increasing in prevalence. We continue to learn about from North America indicate that more accurate estimates the mechanisms involved in these processes and the are likely about 5% in children and 3% to 4% among adults factors that may promote tolerance as opposed to allergy. [1••]. A small group of foods (milk, egg, wheat, soy, At this point, management of food allergy consists of peanut, tree nuts, fish, and shellfish) accounts for most food allergen avoidance and readiness to manage an accidental allergic reactions. Data from the United Kingdom and the exposure reaction, but using current knowledge of United States indicate that the prevalence of peanut allergy gastrointestinal immunity, researchers are investigating in particular has recently doubled and now likely exceeds immunomodulatory approaches that will provide “active” 1% among school-aged children [2, 3], although some therapy for food allergy and induce tolerance. Oral recent evidence indicates that this increase may have immunotherapy is one impor