Update on Infection and Antibiotics in Asthma英文电子书.pdf

Curr Allergy Asthma Rep (2010) 10:67–73 DOI 10.1007/s11882-009-0086-2 Update on Infection and Antibiotics in Asthma Donald R. Rollins David A. Beuther Richard J. Martin Published online: 7 January 2010 # Springer Science+Business Media, LLC 2010 Abstract Asthma pathogenesis seems to be a result of a illnesses causing most asthma exacerbations, but that may be complex mixture of genetic and environmental influences. simply because atypical bacteria are difficult to culture. There is evidence that Mycoplasma pneumoniae and Evidence of bacterial pathogens in the airways of asthmatic Chlamydophila pneumoniae (formerly known as Chlamydia patients is being reported in an increasing number of studies, pneumoniae ) play a role in promoting airway inflammation as is their association with acute and chronic asthma and that could contribute to the onset and clinical course of future asthma diagnosis [1–6]. Increasing evidence suggests asthma. Evidence also indicates that when antimicrobial that atypical respiratory pathogens such as Chlamydophila therapy can eradicate or suppress these organisms, it may be pneumoniae and Mycoplasma pneumoniae may contribute to possible to alter the course of the disease. Certain macrolide the pathogenesis of stable asthma and asthma exacerbations antibiotics have been shown to improve control of asthma [7]. There is also evidence that viral infections, and even symptoms and lung function in patients diagnosed with bacterial or fungal infections, induce immunologic changes acute C. pneumoniae or M. pneumoniae infection. Positive that alter the clinical expression of asthma and other airway polymerase chain reaction studies for C. pneumoniae or M. diseases. Of emerging interest is