Toll like Receptors in Systemic Lupus Erythematosus Potential Targets for Therapeutic Intervention英文电子书.pdfVIP

Curr Allergy Asthma Rep (2012) 12:1–7 DOI 10.1007/s11882-011-0234-3 BASIC AND APPLIED SCIENCE (M FRIERI, SECTION EDITOR) Toll-like Receptors in Systemic Lupus Erythematosus: Potential Targets for Therapeutic Intervention Christopher G. Horton A. Darise Farris Published online: 16 November 2011 # Springer Science+Business Media, LLC 2011 Abstract Toll-like receptors (TLRs) have attracted in- Introduction creased attention in recent years, not only for their role in sensing conserved microbial components, but also in the Toll-like receptors (TLRs) are components of the innate realm of autoimmunity. Although TLRs are most widely immune system specialized in the recognition of commonly known for their capacity to detect conserved motifs of represented microbial motifs, or pathogen-associated mo- infectious agents, mounting evidence indicates that these lecular patterns, including bacterial lipopolysaccharide, innate receptors also promote autoimmune conditions by flagellin, double-stranded and single-stranded RNA, and causing uncontrolled autoinflammation as a result of unmethylated CpG DNA, among others [ 1]. Innate recep- chronic recognition of self. In response to the need for tors such as TLRs provide early immune signals necessary modern approaches to treatment of autoimmune diseases, for effective immune responses that are required for several groups have begun investigating ways to target overcoming infection. Once triggered by its respective TLRs as new therapeutic options for autoimmune con- ligand, a pattern-recognition receptor initiates a signaling ditions. Here we discuss recent data describing advances in cascade beginning with an adapter