The use of macrolides in treatment of upper respiratory tract infections英文电子书.pdf

The Use of Macrolides in Treatment of Upper Respiratory Tract Infections Aleksandra K. Wierzbowski, MSc, Daryl J. Hoban, PhD, Tamiko Hisanaga, PhD, Mel DeCorby, MSc, and George G. Zhanel, PhD Corresponding Author Introduction George G. Zhanel, PhD Antimicrobial resistance is a growing problem among Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, MS673-Microbiology, respiratory tract pathogens. Resistance to β-lactam drugs Health Sciences Centre, 820 Sherbrook Street, among Streptococcus pneumoniae and Haemophilus influ- Winnipeg, Manitoba R3A 1R9, Canada. enzae is escalating [1••]. Macrolides have played a key E-mail: ggzhanel@pcs.mb.ca role in the treatment of community-acquired respiratory Current Allergy and Asthma Reports 2006, 6: 171– 181 tract infections (RTIs) [2••–4••]; however, their use may Current Science Inc. ISSN 1529-7322 be compromised by intrinsic and acquired resistance Copyright © 2006 by Current Science Inc. [1••]. Many reports are available describing increasing macrolide resistance in streptococci species worldwide [1••,3••,5••,6,7•,8,9]. The emergence of macrolide resis- Antimicrobial resistance is a growing problem among tance, particularly in S. pneumoniae and Streptococcus upper respiratory tract pathogens. Res