Should Newborns be Screened for Immunodeficiency Lessons Learned from Infants with Recurrent Otitis Media英文电子书.pdf

Curr Allergy Asthma Rep (2011) 11:491–498 DOI 10.1007/s11882-011-0221-8 OTITIS (DAVID P. SKONER, SECTION EDITOR) Should Newborns be Screened for Immunodeficiency? Lessons Learned from Infants with Recurrent Otitis Media Yesim Yilmaz-Demirdag Published online: 8 September 2011 # Springer Science+Business Media, LLC 2011 Abstract Recurrent otitis media in children is considered Detailed history and careful physical examination as one of the warning signs of primary immunodeficiencies well as immunologic laboratory evaluation identify (PIDs), particularly antibody deficiencies. Infants who have most of the patients with primary immunodeficiencies the most serious and potentially lethal form of PID, severe (PIDs). In our clinic, we have diagnosed a variety of combined immunodeficiency (SCID), sometimes present PIDs in patients who have recurrent ear infections. One with recurrent otitis media. Most of the time, because of the of the most interesting cases we have seen was severity of the immune defect, they develop more serious diagnosed by just history and physical examination. and systemic infections. SCID is distinct among the PIDs The patient was a 6-year-old boy who was referred by and considered a pediatric emergency. Diagnosing SCID his primary care physician for evaluation for recurrent during the newborn period is crucial because survival respiratory tract infections. His past medical history completely depends on early diagnosis and treatment. was significant for mild cerebral palsy presenting as Mortality declines significantly if immune reconstitution is “clumsiness” that started at about 1