Fractional anisotropy value by diffusion tensor magnetic resonance imaging as a predictor of cell density and proliferation activity of glioblastomas英文电子书.pdf

Surgical Neurology 63 (2005) 56–61 Imaging Fractional anisotropy value by diffusion tensor magnetic resonance imaging as a predictor of cell density and proliferation activity of glioblastomas a,* a b c Takaaki Beppu, MD , Takashi Inoue, MD , Yuji Shibata, PhD , Noriyuki Yamada, PhD , Akira Kurose, MDb a a d , Kuniaki Ogasawara, MD , Akira Ogawa, MD , Hiroyuki Kabasawa, DEng Departments of aNeurosurgery, bFirst Department of Pathology, and cClinical Pathology, Iwate Medical University, Morioka 020-8505, Japan dGE Yokogawa Medical Systems, Tokyo, Japan Received 4 March 2003; accepted 12 February 2004 Abstract Background: In vivo, water diffusion displays directionality due to presence of complex microstructural barriers in tissue. The extent of directionality of water diffusion can be expressed as a fractional anisotropy (FA) value using diffusion tensor magnetic resonance imaging (DTI). The FA value has been suggested as an indicator of the cell density of astrocytic tumors. The aim of the present stud