The role of food allergy in atopic dermatitis英文电子书.pdf

The Role of Food Allergy in Atopic Dermatitis Pia J. Hauk, MD Corresponding author sleep disturbance and an overall decrease in quality of life Pia J. Hauk, MD Department of Pediatrics, National Jewish Medical and Research for affected patients and their families [3]. Center, J320, 1400 Jackson Street, Denver, CO 80206, USA. AD is frequently associated with allergic sensitization, E-mail: haukp@njc.org elevated serum IgE levels, and a family history of atopic Current Allergy and Asthma Reports 2008, 8:188–194 diseases [1]. Despite ongoing controversy about the role Current Medicine Group LLC ISSN 1529-7322 of food allergens in AD [4], numerous studies have estab- Copyright © 2008 by Current Medicine Group LLC lished that food allergies play a pathogenic role [5,6], and food allergy and atopic dermatitis often occur together [7]. Based on oral challenges, three patterns of cutaneous Atopic dermatitis (AD) is a chronic, pruritic, inflamma- reactions to food have been described in patients with AD tory skin disease affecting more than 10% of all children. [8,9]: immediate reactions, within minutes after ingesting Sensitization to foods triggers isolated skin symptoms food, without exacerbation of AD; early exacerbations in about 30% of children. These symptoms include of AD related to pruritus and scratching; and late exac- immediate reactions within minutes after ingesting