Comparison of an intraoperative infusion of dexmedetomidine or remifentanil on perioperative haemodynamics, hypnosis and sedation, and postoperative pain control英文电子书.pdf

The Journal of International Medical Research 2011; 39: 1890 – 1899 Comparison of an Intraoperative Infusion of Dexmedetomidine or Remifentanil on Perioperative Haemodynamics, Hypnosis and Sedation, and Postoperative Pain Control HS UNG, JD OO, YS EON, JA LEE, DW KIM, JH IN, HY RHEE AND JW CHOI Department of Anaesthesiology and Pain Medicine, St Vincent’s Hospital, The Catholic University of Korea, Suwon, Republic of Korea This prospective, randomized, double- min, starting at the end of surgery to the blind study compared the effects of time in the PACU. Modified observer’s dexmedetomidine and remifentanil on assessment of alertness scores were haemodynamic stability, sedation and significantly lower in the postoperative pain control in the dexmedetomidine group than in the postanaesthetic care unit (PACU). Fifty remifentanil group at 0, 5 and 10 min consecutive patients scheduled for total after arrival in the PACU. Blood pressure laparoscopic hysterectomy were and heart rate in the dexmedetomidine randomly assigned to receive infusions of group were significantly lower than that either dexmedetomidine (1 µg/kg) i.v. recorded in the remifentanil group in the over 10 min followed by 0.2 – 0.7 µg/kg PACU. Dexmedetomidine, at the doses per h continuous i.v. infusion or used in this study, had a significant remifentanil (0.8 – 1.2 µg/kg) i.v. over 1 advantage over remifentanil in terms of min followed by 0.05 – 0.1 µg/kg i.v. per postoperative haemodynamic stability. KEY WORDS: DEXMEDETOMIDINE; REMIFEN