Selective roles and dysregulation of interleukin 10 in allergic disease英文电子书.pdf

Selective Roles and Dysregulation of Interleukin-10 in Allergic Disease Judith A. Woodfolk, MB ChB, PhD Corresponding author protective immune responses directed against allergens. Judith A. Woodfolk, MB ChB, PhD Asthma and Allergic Diseases Center, University of Virginia Health In this article, we review evidence supporting a role for IL- System, PO Box 801355, Charlottesville, VA 22908-1355, USA. 10 in the regulation of the allergic response, and discuss E-mail: jaw4m@virginia.edu how failure of IL-10–mediated regulatory mechanisms Current Allergy and Asthma Reports 2006, 6:40– 46 may contribute to aberrant production of IgE. Current Science Inc. ISSN 1529-7322 Copyright © 2006 by Current Science Inc. Regulatory T Cells as a Source of Interleukin-10 IL-10 is a potent anti-inflammatory cytokine, as evi- There is mounting evidence to support a role for denced by its ability to inhibit inflammatory bowel interleukin (IL)-10 in the regulation of both allergic and disease and autoimmune disease, and to control infec- nonallergic immune responses. The current view is that tion by pathogenic agents such as the parasite, Leishmania IL-10 influences Th2-driven allergic processes by alter- major [1–6]. In addition, IL-10 has been shown to limit ing the interplay bet