Review of the protective effects of rutin on the metabolic function as an important dietary flavonoid英文电子书.pdf

J Endocrinol Invest (2014) 37:783–788 DOI 10.1007/s40618-014-0096-3 REVIEW Review of the protective effects of rutin on the metabolic function as an important dietary flavonoid Hossein Hosseinzadeh • Marjan Nassiri-Asl Received: 27 March 2014 / Accepted: 14 May 2014 / Published online: 31 May 2014 Italian Society of Endocrinology (SIE) 2014 Abstract Introduction Background In recent years, flavonoids have been revealed to be helpful in the treatment of many diseases. Rutin (3,30 0 ,4 ,5,7-pentahydroxyflavone-3-rhamnoglucoside) Rutin (3,30 0 is a flavonoid of the flavonol-type found in many typical ,4 ,5,7-pentahydroxyflavone-3-rhamnogluco- side) is an important flavonoid that is consumed in the daily plants, such as buckwheat, passion flower, apple, and tea. diet. It is also known as vitamin P and quercetin-3-O-ru- Some plants that contain rutin and their quantities were tinoside. In addition, it is found in many food items, veg- summarized in Table 1. In addition, it is an important die- etables, and beverages. The cytoprotective effects of rutin, tary constituent of food and plant-based beverages [ 1–4]. including gastroprotective, hepatoprotective, and anti-dia- Furthermore, it is known as vitamin P and quercetin-3-O- betic effects, have been shown in several studies. Fur- rutinoside (Fig. 1) [5, 6]. Rutin is the main glycoside (a 3-O- thermore, rutin has several pharmacological effects such as rhamnoglucoside) form of quercetin, which is the most anti-inflammatory and anti-glycation activities. abundant flavonol in vegetables and fruits