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Unproven Diagnostic and
Therapeutic Techniques
John M. James, MD
Address Cytotoxic Testing
Colorado Allergy and Asthma Centers, PC, 1136 East Stuart Street, The cytotoxic test (also known as the leukocyotoxic test)
Suite 3200, Fort Collins, CO 80524, USA. was initially described approximately 50 years ago and has
E-mail: jamesftco@earthlink.net
been advocated especially as a potential diagnostic method
Current Allergy and Asthma Reports 2002, 2:87–91 for food allergy [1]. In addition, this method has been
Current Science Inc. ISSN 1529–7322
Copyright © 2002 by Current Science Inc. used to diagnose allergy in a wide range of disorders,
including rhinitis, asthma, dermatitis, headaches,
gastrointestinal symptoms, hearing disorders, genitouri-
Over the years, there have been many procedures that
nary diseases and obesity.
either have no diagnostic value for any allergic disease or
This diagnostic test claims that morphologic changes in
are inappropriate for the diagnosis and treatment of allergy.
peripheral blood leukocytes in contact with allergen in
These procedures fall into the category of unproven diag-
vitro indicate that the patient is allergic to that particular
nostic and therapeutic
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