The Role of the Histamine H4 Receptor in Atopic Dermatitis英文电子书.pdf

Curr Allergy Asthma Rep (2011) 11:21–28 DOI 10.1007/s11882-010-0162-7 The Role of the Histamine H4 Receptor in Atopic Dermatitis Susanne Mommert Maria Gschwandtner Ralf Gutzmer Thomas Werfel Published online: 23 November 2010 # Springer Science+Business Media, LLC 2010 Abstract The pathology of atopic dermatitis is orchestrated Introduction on the cellular level by several different cell types in the characteristic skin lesions. In such lesions, histamine as a Atopic dermatitis (AD) is a chronic inflammatory skin mediator of many biological functions is also present in disease with a characteristic phenotype of intensely high concentrations. Most of the cells involved in the pruritic, erythematous papules associated with excoriation inflammatory responses express the histamine H1 and H2 and oozing exudation [ 1]. It has been shown that AD has receptors, but drugs targeting these receptors are not a complex etiology by activating multiple immunologic clinically effective. The discovery of the fourth histamine and inflammatory pathways [2]. AD inflammation dis- receptor, which is differentially expressed on immune and plays two phases that are orchestrated by a differential nonimmune cells, has shed new light on the actions of infiltrate of mononuclear cells in the dermis and by a histamine in the complexity of atopic dermatitis. In this switch of the local tissue expression of proinflammatory review, we describe a possible genetic impact on the cytokines and chemokines. The initial phase is associated expression level of the histamine H4 receptor and summa- with an increase in T-helper type 2 (Th2) cells