What causes itch in atopic dermatitis英文电子书.pdf

What Causes Itch in Atopic Dermatitis? Gil Yosipovitch, MD, and Alexandru D.P. Papoiu, MD, PhD Corresponding author often are unaware of the extent to which they are scratch- Gil Yosipovitch, MD Departments of Dermatology and Neurobiology and Anatomy, ing, especially during the night, thus further contributing Wake Forest University School of Medicine, Winston-Salem, to skin inl ammation [3]. NC 27157, USA. Until recently, most research pertaining to pruritus E-mail: gyosipov@wfubmc.edu has focused on its peripheral mechanisms. However, Current Allergy and Asthma Reports 2008, 8:306–311 cognitive and affective aspects of the itch experience Current Medicine Group LLC ISSN 1529-7322 indicate central mechanisms are also important. A Copyright © 2008 by Current Medicine Group LLC variety of central and peripheral mediators have been suggested to play a role in the pathophysiology of atopic eczema itch. This review covers peripheral and central Itch, the hallmark of atopic dermatitis, has a signifi cant mechanisms and mediators involved in the pathogenesis impact on quality of life for patients with this dis- of itch in atopic dermatitis. ease. Various central and peripheral mediators have been suggested to play a role in the pa