Pathogenesis of chronic rhinosinusitis英文电子书.pdf

Pathogenesis of Chronic Rhinosinusitis Paul Van Cauwenberge, MD, PhD, Helen Van Hoecke, MD, and Claus Bachert, MD, PhD Corresponding author Paul Van Cauwenberge, MD, PhD morbidity and considerable socioeconomic consequences. Department of Otorhinolaryngology, Ghent University, Making an accurate estimation of the prevalence of CRS, De Pintelaan 185, 9000 Ghent, Belgium. however, is impossible because of the heterogeneity of the E-mail: paul.vancauwenberge@ugent.be disorder, the lack of a precise and usable definition and Current Allergy and Asthma Reports 2006, 6:487–494 classification, and the often ill-defined diagnostic criteria Current Science Inc. ISSN 1529-7322 in publications. In the United States, population-based Copyright © 2006 by Current Science Inc. prevalence data for CRS ranging from 1.96% (CRS defi- nition based on assignment of International Classification of Diseases, Ninth Revision [ICD-9] codes) [1] to 15.5% Chronic rhinosinusitis (CRS) is a heterogenous disorder (CRS defined as having “sinus trouble” for more than 3 and represents a major public health problem. Although months) [2] have been reported. insights into the pathophysiology of CRS have largely In response to the lack of standardization, the expanded over the last two decades, the exact etiology