Oral tolerance and gut oriented immune response to dietary proteins英文电子书.pdf

Oral Tolerance and Gut-Oriented Immune Response to Dietary Proteins Oral Alpan, MD Address involved in this response. The second part summarizes the Laboratory of Cellular and Molecular Immunology, National Institute of clinical applications of the field. Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room 111, 9000 Rockville Pike, Bethesda, MD 20850, USA. E-mail: oalpan@niaid.nih.gov Current Allergy and Asthma Reports 2001, 1:572–577 Gut-Oriented Immune Response Current Science Inc. ISSN 1529–7322 to Dietary Antigens Copyright © 2001 by Current Science Inc. Immune architecture of the gut More than 50% of the immune system is within the gas- trointestinal tract either in the form of organized gut-associ- Dietary proteins induce both a local immune response char- ated lymphoid tissue (GALT) or in the lamina propria and acterized by IgA production and systemic immune response intraepithelial compartment as scattered lymphoid cells. characterized by the production of TH2/TH3 cytokines. By The organized GALT includes approximately 30,000 scat- influencing the class of immune response, the gut enhances tered, solitary B-cell follicles and approximately seven to the efficacy of immunity against proteins that enter the body