Radiation Survival Parameters of Antineoplastic Drug sensitive and resistant Human Ovarian Cancer Cell Lines and Their Modification by Buthionine Sulfoximine英文电子书.pdf

[CANCER RESEARCH 45, 2110-2115, May 1985] Radiation Survival Parameters of Antineoplastic Drug-sensitive and -resistant Human Ovarian Cancer Cell Lines and Their Modification by Buthionine Sulfoximine Karen G. Louie, Brent C. Behrens, Timothy J. «insella,Thomas C. Hamilton, Karen R. Grotzinger, Wilma M. McKoy, Margaret A. Winker, and Robert F. Ozols1 Medicine Branch [K. G. L, B. C. B., T. C. H., K. R. G., W. M. M., M. A. W., R. F. O.] and Radiation Oncology Branch [T. J. K.J, Division of Cancer Treatment, National Cancer Institute, Bethesda, MD 20205 ABSTRACT are currently under investigation at the National Cancer Institute and elsewhere (18, 24, 28). The designs of these clinical trials The optimum integration of chemotherapy and irradiation is of integrating irradiation and chemotherapy have been empirically potential clinical significance in the treatment of ovarian cancer. derived, and the preliminary results of most studies have failed A series of human ovarian cancer cell lines have been developed to demonstrate a marked advantage over the use of combination in which dose-response relationships to standard anticancer chemotherapy alone (24, 28). Experimental studies on patterns drugs have been determined, and the patterns of cross-resist of radiation and chemotherapeutic sensitivity in relevant model ance between