Pharmacological effects and pharmacokinetics properties of Radix Scutellariae and its bioactive flavones英文电子书.pdfVIP

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Pharmacological effects and pharmacokinetics properties of Radix Scutellariae and its bioactive flavones英文电子书.pdf

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BIOPHARMACEUTICS DRUG DISPOSITION Biopharm. Drug Dispos. 32: 427–445 (2011) Published online 19 September 2011 in Wiley Online Library () DOI: 10.1002/bdd.771 Pharmacological effects and pharmacokinetics properties of Radix Scutellariae and its bioactive ﬂavones a b a,* Chenrui Li , Ge Lin , and Zhong Zuo aSchool of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR bSchool of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR ABSTRACT: Radix Scutellariae is the dried root of the medicinal plant Scutellariae baicalensis Georgi. It exhibits a variety of therapeutic effects and has a long history of application in traditional formulations as well as in modern herbal medications. It has been conﬁrmed that ﬂavonoids are the most abundant constituents and induce these therapeutic effects. Six ﬂavones are proven to be the major bioactive ﬂavones in Radix Scutellariae existing in the forms of aglycones (baicalein, wogonin, oroxylin A) and glycosides (baicalin, wogonoside, oroxylin A-7-glucuronide). All six ﬂavones are pharmacologically active and show great potential in the treatment of inﬂammation, cancers and virus-related diseases. The current review covers the preparation of the herb Radix Scutellariae, quantiﬁcation of its major bioactive ingredients, and pharmacological effects of the proposed six bioactive ﬂavones. In addition, this review summarizes the pharmacokinetic proﬁles of the bioactive ﬂavones reported so far that could be used for further improvement of their pharmacokinetic study. Moreover, due to abundant co-occurring bioactive components in Radix Scutellariae, our review further documents the pharmacokinetic interactions