The anti diabetic effect of anthocyanins in streptozotocin induced diabetic rats through glucose transporter 4 regulation and prevention of insulin resistance and pancreatic apoptosis英文电子书.pdf

Mol. Nutr. Food Res. 2009, 53, 1419–1429 DOI 10.1002/mnfr.200800526 1419 RESEARCH ARTICLE The anti-diabetic effect of anthocyanins in streptozotocin-induced diabetic rats through glucose transporter 4 regulation and prevention of insulin resistance and pancreatic apoptosis 1 1 2 3 Irina Tsoy Nizamutdinova , Yong Chun Jin , Jong Il Chung , Sung Chul Shin , 3 1 1 ,1 1 Sung Joong Lee , Han Geuk Seo , Jae Heun Lee , Ki Churl Chang and Hye Jung Kim 1 Department of Pharmacology, School of Medicine and Institute of Health Sciences, Gyeongsang Nat’l University, Jinju, Republic of Korea 2 Department of Agronomy, Research Institute of Life Science, Gyeongsang Nat’l University, Jinju, Republic of Korea 3 Department of Chemistry, Research Institute of Life Science, Gyeongsang Nat’l University, Jinju, Republic of Korea Hyperglycemia, abnormal lipid and antioxidant profiles are the most usual complications in Received: November 14, 2008 diabetes mellitus. Thus, in this study, we investigated the anti-diabetic and anti-oxidative effects of Revised: February 27, 2009 anthocyanins (ANT) from black soybean seed coats in streptozotocin (STZ)-induced diabetic rats. Accepted: March 4, 2009 The administration of ANT markedly decreased glucose levels and improved heart hemodynamic function (left ventricular end diastolic pressure, 7dp/dt parameters). ANT not only enhanced STZ-mediated insulin level decreases, but also decreased the triglyceride levels induced by STZ injection in serum. Diabetic rats exhibited a lower expression of glucose transporter 4 proteins in the membrane f