The problem of anaphylaxis and mastocytosis英文电子书.pdf

The Problem of Anaphylaxis and Mastocytosis Ulrich R. Müller, MD, and Gabrielle Haeberli, MD Corresponding author and unconsciousness after honeybee stings in 1967 and Ulrich R. Müller, MD 1984, whereas vespid stings were always well tolerated Allergy Division, Department of Medicine, Spital Ziegler, [1]. Judging from history and skin tests, there was no Spitalnetzbern, Morillonstrasse 75-91, CH-3007, Bern, Switzerland. atopic constitution. In the presence of high exposure to E-mail: ulrich.mueller@spitalnetzbern.ch Hymenoptera stings (as a hobby gardener) and positive Current Allergy and Asthma Reports 2009, 9:64–70 skin tests and specii c serum IgE antibodies to bee venom, Current Medicine Group LLC ISSN 1529-7322 immunotherapy with bee venom was started in 1984 but Copyright © 2009 by Current Medicine Group LLC caused repeated systemic allergic side effects. Finally, the maintenance dose of 100 μg was well tolerated under antihistamine premedication and passive immunotherapy Mastocytosis is a rare disease characterized by an ele- with beekeeper gammaglobulin [2]. Venom immuno- vated whole body mast cell number. Anaphylaxis is a therapy (VIT) could be continued without premedication severe, generalized hypersensitivity reaction with rapid until 1988. During this treatment, three bee stings were onset. The problem of anaphylaxis and mastocytosis well tole