Listeria and autophagy escape Involvement of InlK, an internalin like protein英文电子书.pdf

Autophagy 8:1, 132–134; January 2012; G 2012 Landes Bioscience Listeria and autophagy escape Involvement of InlK, an internalin-like protein Laurent Dortet,1,2,3,4 Serge Mostowy1,2,3 and Pascale Cossart1,2,3,* 1Institut Pasteur; Unité des interactions Bactéries-Cellules; Paris, France; 2INSERM; U604; Paris, France; 3INRA; USC 2020; Paris, France; 4Service de Bactériologie- Virologie; Hôpital de Bicêtre; Assistance Publique/Hôpitaux de Paris; Faculté de Médecine et Université Paris-Sud; Paris, France Autophagy is a cell-autonomous interactions and fundamental processes mechanism of innate immunity in cell biology, and the study of actin that protects the cytosol against bacter- rearrangements upon entry and intra- ial infection. Invasive bacteria, including cellular movements is a well-recognized Listeria monocytogenes, have thus evolved example of how bacterial-induced pro- strategies to counteract a process that cesses can yield insight into basic cellular limits their intracellular growth. ActA is processes. Listeria ActA triggers the recruit- © 2012 Landes Bioscience. a surface protein produced by L. mono- ment of the Arp2/3 complex to mediate cytogenes to polymerize actin and mediate actin polymerization and propel bacteria