Curcumin (Diferuloyl methane) Sensitizes Human Prostate Cancer Cells to TRAIL Apo2L induced Apoptosis by Suppressing NF kB via Inhibition of Prosurvival Akt Signaling Pathway英文电子书.pdf

JPET Fast Forward. Published on February 8, 2007 as DOI:10.1124/jpet.106.117721 JPET #117721 Curcumin (Diferuloyl-methane) Sensitizes Human Prostate Cancer Cells to TRAIL/Apo2L-induced Apoptosis by Suppressing NF-κB via Inhibition of Pro- survival Akt Signaling Pathway Dorrah Deeb, Hao Jiang, Xiaohua Gao, Shaza Al-Holou, Andrew L. Danyluk, Scott A. Dulchavsky, and Subhash C. Gautam Department of Surgery (D.D., X.G., S.A-H., A.L.D., S.A.D., S.C.G.) and Department of Neurology (H.J.), Henry Ford Health System, Detroit, Michigan 1 Copyright 2007 by the American Society for Pharmacology and Experimental Therapeutics. JPET #117721 Running title: Curcumin sensitization of prostate cancer cells to TRAIL Correspondence to: Subhash C. Gautam, PhD, Surgical Research 4D, One Ford Place Detroit, MI 48202 Telephone: (313) 874-6998 Fax: (313) 874-3770 e-mail: sgautam1@hfhs.org Number of text pages : 20 Number of tables : 0 Number of figures : 6 Number of references : 40 Number of words in Abstract : 249 Number of words in Introduction : 719 Number of words in Discussion : 1282 Nonstandard abbreviations : TRAIL, tumor necrosis factor-related apoptosis-inducing ligand ; NF-κB, nuclear factor kappaB ; IKK, IκB kinase ; PTEN, phosphatase and tensin homologue deleted on chromosome ten, siRNA, small inhibitory RNA ; CaP, carcinoma of prostate Section assignment : Cellular and Molecular 2 JPET #117721 Abstract Our previous