Autophagosome assembly and cargo capture in the distal axon英文电子书.pdf

AUTOPHAGIC PUNCTUM Autophagy 8:5, 1–3; May 2012; G 2012 Landes Bioscience Autophagosome assembly and cargo capture in the distal axon Sandra Maday and Erika L.F. Holzbaur* Department of Physiology; Perelman School of Medicine at the University of Pennsylvania; Philadelphia, PA USA Autophagy is an essential lysosomal architecture with axons that can reach up to degradation pathway in neurons, one meter in length. How degradative yet the basic mechanisms involved are pathways respond to protein and organelle poorly understood. Here, we discuss our damage along the length of the axon is recent study in which we define autopha- poorly understood. Where are autophago- gosome dynamics in primary neurons. somes generated in neurons? How do they We find that autophagosomes initiate at mature into compartments capable of the distal tip of the axon in primary efficient degradation? Does autophagy neurons and undergo retrograde trans- require long-range transport along the axon port toward the cell soma. As they move or is it executed within a localized region? © 2012 Landes Bioscience.