Bioavailability of capsaicin and its implications for drug delivery英文电子书.pdf

Journal of Controlled Release 196 (2014) 96 –105 Contents lists available at ScienceDirect Journal of Controlled Release journal homepage: www. / locate/jconrel Review Bioavailability of capsaicin and its implications for drug delivery William D. Rollyson 1, Cody A. Stover 1, Kathleen C. Brown, Haley E. Perry, Cathryn D. Stevenson, Christopher A. McNees, John G. Ball, Monica A. Valentovic, Piyali Dasgupta ⁎ Department of Pharmacology, Physiology and Toxicology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, USA a r t i c l e i n f o a b s t r a c t Article history: The dietary compound capsaicin is responsible for the “hot and spicy” taste of chili peppers and pepper extracts. It Received 22 July 2014 is a valuable pharmacological agent with several therapeutic applications in controlling pain and inflammation. Accepted 26 September 2014 Emerging studies show that it displays potent anti-tumor activity in several human cancers. On a more basic re- Available online 12 October 2014 search level, capsaicin has been used as a ligand to activate several types of ion-channel receptors. The pharma- cological activity of capsaicin-like compounds is dependent on several factors like the dose, the route of Keywords: admi