Cytotoxicity of the mycotoxins deoxynivalenol and ochratoxin A on Caco 2 cell line in presence of resveratrol英文电子书.pdf

Toxicology in Vitro 29 (2015) 1639–1646 Contents lists available at ScienceDirect Toxicology in Vitro journal homepage: www.elsevi /locate/toxinvit Cytotoxicity of the mycotoxins deoxynivalenol and ochratoxin A on Caco-2 cell line in presence of resveratrol G. Cano-Sancho a, C.A. González-Arias a, A.J. Ramos a, V. Sanchis a, M.L. Fernández-Cruz b,⇑ a Applied Mycology Unit, Food Technology Department, XaRTA-UTPV, Agrotecnio Center, University of Lleida, Av. Rovira Roure, 191, 25198 Lleida, Spai n b National Institute for Agricultural and Food Research and Technology (INIA), Department of Environment, Carretera de la Coruña Km 7.5, 28040 Madrid, Spain a r t i c l e i n f o a b s t r a c t Article history: Exposure to mycotoxins through dietary food intake involves a highly complex scenario where Received 29 January 2015 co-contamination of different mycotoxins has been frequently demonstrated. On the other hand, the Revised 17 June 2015 effect of the interaction of mycotoxins with other generally considered beneficial food components, as Accepted 18 June 2015 the antioxidants, has been scarcely studied. The main goal of the present work was to assess the cytotoxic Available online 19 June 2015 effects on Caco-2 cells of the mycotoxins deoxynivalenol (DON) and ochratoxin A (OTA), alone or com- bined, and to explore potential protective effects of resveratrol (RES), an ant