Selenium and vitamin E, natural antioxidants, protect rat cerebral cortex against dimethoate induced neurotoxicity英文电子书.pdf

Pesticide Biochemistry and Physiology 101 (2011) 165–174 Contents lists available at SciVerse ScienceDirect Pesticide Biochemistry and Physiology journal homepage: www.else /locate/pest Selenium and vitamin E, natural antioxidants, protect rat cerebral cortex against dimethoate-induced neurotoxicity Ibtissem Ben Amara a, Nejla Soudani a,1, Ahmed Hakim b,1, Afef Troudi a, Khaled Mounir Zeghal b, Tahia Boudawara c, Najiba Zeghal a,⇑ a Animal Physiology Laboratory, Sfax Faculty of Science, University of Sfax, BP 1171, 3000 Sfax, Tunisia b Laboratory of Pharmacology, Medicine Faculty, University of Sfax, 3029 Sfax, Tunisia c Anatomopathology Laboratory, CHU Habib Bourguiba, University of Sfax, 3029 Sfax, Tunisia a r t i c l e i n f o a b s t r a c t Article history: Pesticides have been used in agriculture to enhance food production by eradicating unwanted insects and Received 13 June 2011 controlling disease vectors, nevertheless occupational exposure to high levels of these compounds can Accepted 26 August 2011 lead to neurodegenerative disorders, characterized by serious oxidative and neurotoxic effects. However, Available online 6 September 2011 there is a lack of consensus as to which determinations are best used to quantify future risks arising from xenobiotic exposure and natural antioxidant interventions. Our study aims to determine the potential Keywords: ability of selenium and/or vitamin E, used as nutritional supplements