Histamine H4 receptor antagonist ameliorates chronic allergic contact dermatitis induced by repeated challenge英文电子书.pdf

Allergy ORIGINAL ARTICLE E X P E R I M E N T A L A L L E R G Y A N D I M M U N O L O G Y Histamine H4 receptor antagonist ameliorates chronic allergic contact dermatitis induced by repeated challenge 1 1 1 1 1 2 M. Seike , K. Furuya , M. Omura , K. Hamada-Watanabe , A. Matsushita H. Ohtsu 1Department of Food and Nutrition Science, Sagami Women’s Junior College, Bunkyo, Sagamihara, Kanagawa, Japan; 2Department of Quantum Science and Energy Engineering, Graduate School of Engineering, Tohoku University, Aramaki, Aobaku, Sendai, Miyagi, Japan To cite this article: Seike M, Furuya K, Omura M, Hamada-Watanabe K, Matsushita A, Ohtsu H. Histamine H4 receptor antagonist ameliorates chronic allergic contact dermatitis induced by repeated challenge. Allergy 2010; 65: 319–326. Keywords Abstract chronic allergic contact dermatitis; cytokine, Background: The present study observed effects of the histamine H4 receptor on histamine; H4 receptor; mast cell. chronic allergic contact dermatitis induced by repeated challenge in mice. Correspondence Methods: Acute contact dermatitis was induced by single epicutaneous challenge of Masahiro Seike, Department of Food and 2,4,6-trinitro-1-chlorobenzene (TNCB) to the ear. Chronic allergic contact dermatitis Nutrition Science, Sagami Women’s Junior was developed by repeated epicutaneous challeng