Oxidative stress in the pathogenesis of asthma英文电子书.pdf

Oxidative Stress in the Pathogenesis of Asthma Russell P. Bowler, MD, PhD Address all organisms have evolved elaborate cellular defenses National Jewish Medical and Research Center, K736a, that are collectively called antioxidants. The imbalance 1400 Jackson Street, Denver, CO, 80206, USA. between reactive oxygen species and antioxidants is called E-mail: BowlerR@njc.org oxidative stress. Oxidative stress is a major feature of Current Allergy and Asthma Reports 2004, 4: 116–122 many respiratory diseases, such as ischemia-reperfusion, Current Science Inc. ISSN 1529-7322 Copyright © 2004 by Current Science Inc. pulmonary fibrosis, chronic obstructive pulmonary disease, and asthma [4] Oxygen’s affinity for electrons is key in understanding Asthma affects 5% to 10% of the population of the United the generation of oxidative stress in vivo. The sequential States. In asthmatics, oxidative stress occurs not only as a addition of electrons to oxygen results in the formation of result of inflammation but also from environmental expo- three species of ROS (Fig. 1): one electron produces super- sure to air pollution. The specific localization of antioxi- - oxide (O2• ), a second electron y