The gut microbiome, probiotics, bile acids axis, and human health英文电子书.pdf

Spotlights Trends in Microbiology June 2014, Vol. 22, No. 6 sensing and Fur and modulates internalization in epithelial cells. J. 8 Sana, T.G. et al. (2013) Divergent control of two type VI secretion Biol. Chem. 287, 27095–27105 systems by RpoN in Pseudomonas aeruginosa . PLoS ONE 8, e76030 6 Russel, A.B. et al. (2013) Diverse type VI secretion phospholipases are 9 Kierbel, A. et al. (2005) The phosphoinositol-3-kinase-protein kinase B/ functionally plastic antibacterial effectors. Nature 496, 508–512 Akt pathway is critical for Pseudomonas aeruginosa strain PAK 7 Lesic, B. et al. (2009) Quorum sensing differentially regulates internalization. Mol. Biol. Cell 16, 2577–2585 Pseudomonas aeruginosa type VI secretion locus I and homologous 10 Edwards, J.L. and Apicella, M.A. (2006) Neisseria gonorrhoeae PLD loci II and III, which are required for pathogenesis. Microbiology 155, directly interacts with Akt kinase upon infection of primary, human, 2845–2855 cervical epithelial cells. Cell. Microbiol. 8, 1253–1271 The gut microbiome, probiotics, bile acids axis, and human health * * Mitchell Lawrence Jones , Catherine Tomaro-Duchesneau , and Satya Prakash Biomedical Technology and Cell Therapy Research Laboratory, Departments of Biomedical Engineering, Physiology and Artificial Cells and Organs Research Center, Faculty of Medicine, McGill University, 3775 University Street, Montreal, Quebec, H3A 2B4, Canada The human gut microbiome produces potent ligands to Bifidobacterium breve, Bifidobacterium infantis, Bifidobac- bile acid receptors, and probiotics could a