Cardiolipin and electron transport chain abnormalities in mouse brain tumor mitochondria lipidomic evidence supporting the Warburg theory of cancer英文电子书.pdf

Cardiolipin and electron transport chain abnormalities in mouse brain tumor mitochondria: lipidomic evidence supporting the Warburg theory of cancer Michael A. Kiebish,* Xianlin Han,† Hua Cheng,† Jeffrey H. Chuang, * and Thomas N. Seyfried1,* Department of Biology,* Boston College, Chestnut Hill, MA; and Department of Internal Medicine,† Washington University School of Medicine, St. Louis, MO Abstract Otto Warburg first proposed that cancer origi- that was followed in time by a gradual dependence on fer- D nated from irreversible injury to mitochondrial respiration, mentation (glycolytic) energy to compensate for the en- o w but the structural basis for this injury has remained elusive. n ergy lost from respiration. Cell viability requires a constant l o Cardiolipin (CL) is a complex phospholipid found almost a delta G′ of ATP hydrolysis of approximately 257 kJ/mol d exclusively in the inner mitochondrial membrane and is in- e