The role of chemokines in virus associated asthma exacerbations英文电子书.pdf

The Role of Chemokines in Virus-Associated Asthma Exacerbations Lara E. Kallal, BA, and Nicholas W. Lukacs, PhD Corresponding author demonstrated a protective effect, such as with inl uenza [2], Nicholas W. Lukacs, PhD Department of Molecular and Cellular Pathology, University of but also a positive correlation between early exposure to Michigan, 4620 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI virus and development of asthma, such as with respiratory 48109, USA. syncytial virus (RSV) [3]. As successful viral clearance is E-mail: nlukacs@med.umich.edu associated with a predominant T-helper type 1 (Th1) effec- Current Allergy and Asthma Reports 2008, 8:443–450 tor response, it is clear that the traditional view suggested Current Medicine Group LLC ISSN 1529-7322 by the hygiene hypothesis of an early, advantageous Th1 Copyright © 2008 by Current Medicine Group LLC response (and deleterious Th2 response) does not necessar- ily inform subsequent disease development. More likely, predisposition to asthma represents a complicated interplay Asthma is a chronic disease characterized by mast cell among genetic factors, environmental exposure, and the activation, mucus hypersecretion, airway obstruction, initiation of early immune events in the lung that affect the infl ux and activation of eosinophils,