Bnip3 mediated defects in oxidative phosphorylation promote mitophagy英文电子书.pdf

AutophAgic punctum AutophAgic punctum Autophagy 7:7, 775-777; July 2011; © 2011 Landes Bioscience Bnip3-mediated defects in oxidative phosphorylation promote mitophagy Robert L. Thomas, Dieter A. Kubli and Åsa B. Gustafsson* Skaggs School of Pharmacy and Pharmaceutical Sciences; University of California San Diego; La Jolla, CA USA he Bcl-2 proteins are best known as Both Bnip3 and Nix are known to acti- Tregulators of the intrinsic mitochon- vate the mitochondrial cell death pathway. drial pathway of apoptosis. However, However, recent studies have demon- recent studies have demonstrated that strated that Bnip3 and Nix also induce they can also regulate autophagy. For mitophagy. The functional role of Bnip3- many years, autophagy was considered mediated autophagy is unclear and has to be a nonselective process where the been reported to be protective as well as autophagosomes randomly sequestered detrimental. To examine the relationship contents in the cytosol to supply the between apoptosis and autophagy, we cells with amino acids and fatty acids investigated whether Bnip3 i