BH3 mimetics reveal the network properties of autophagy regulatory signaling cascades英文电子书.pdf

AutophAgic punctum Autophagy 7:8, 914-916; August 2011; © 2011 Landes Bioscience BH3 mimetics reveal the network properties of autophagy-regulatory signaling cascades Shoaib Ahmad Malik,1-3 Shensi Shen,1-3 Guillermo Mariño,1-3 Amena BenYounès,1-3 Maria Chiara Maiuri1-3,† and Guido Kroemer1,3-6,†,* 1INSERM; U848; Villejuif, France; 2Université Paris Sud; Paris 11; Villejuif, France; 3Metabolomics Platform; Institut Gustave Roussy; Villejuif, France; 4Centre de Recherche des Cordeliers; Paris, France; 5Pôle de Biologie; Hôpital Européen Georges Pompidou; Paris, France; 6Université Paris Descartes; Paris, France †These authors contributed equally to this work. eclin 1 usually interacts with sev- Numerous signal transducers involved in Beral autophagy-inhibitory proteins the cellular response to stress and damage including the anti-apoptotic proteins also participate in the control of macro- from the Bcl-2 family (Bcl-2, Bcl-XL autophagy (herewith referred to as “auto- and Mcl-1) and the inositol-1,4,5 tri- phagy”). This applies for instance to the sphosphate (IP3) receptor, which inter- proteins from the Bcl-2 family, which can acts with Beclin 1 indirectly via Bcl-2. be divided into three categories, (i) the ©2011 Landes Bioscience. Beclin 1 possesses a BH3 domain that anti-apoptotic multidomain proteins (Bcl-