Evidence for disease and antipsychotic medication effects in post mortem brain from schizophrenia patients英文电子书.pdf

Molecular Psychiatry (2011) 16, 1189–1202 2011 Macmillan Publishers Limited All rights reserved 1359-4184/11 /mp ORIGINAL ARTICLE Evidence for disease and antipsychotic medication effects in post-mortem brain from schizophrenia patients 1 2 1 1 2 1,3 MK Chan , TM Tsang , LW Harris , PC Guest , E Holmes and S Bahn 1Department of Chemical Engineering and Biotechnology, Institute of Biotechnology, University of Cambridge, Cambridge, UK; 2 Faculty of Medicine, Department of Surgery and Cancer, Biomolecular Medicine, Imperial College, London, UK and 3 Department of Neuroscience, Erasmus MC, Rotterdam, The Netherlands Extensive research has been conducted on post-mortem brain tissue in schizophrenia (SCZ), particularly the dorsolateral prefrontal cortex (DLPFC). However, to what extent the reported changes are due to the disorder itself, and which are the cumulative effects of lifetime medication remains to be determined. In this study, we employed label-free liquid chromatography–mass spectrometry-based proteomic and proton nuclear magnetic reso- nance-based metabonomic profiling approaches to investigate DLPFC tissue from two cohorts of SCZ patients grouped according to their lifetime antipsychotic dose, together with tissue from bipolar disorder (BPD) subjects, and normal controls (n = 10 per group). Both techniques showed profound changes in tissue from low-cumulative-medication SCZ subjects, but few chan