1,3 Butadiene：I. Review of metabolism and the implications to human health risk assessment英文电子书.pdf

Critical Reviews in Toxicology, 2010; 40(S1): 1–11 R E V I E W A R T I C L E 1,3-Butadiene: I. Review of metabolism and the implications to human health risk assessment 1,2 3 4,6 5,6 Christopher R� Kirman , Richard J� Albertini , Lisa M� Sweeney * , and Michael L� Gargas 1 2 3 Summit Toxicology, Orange, Ohio, USA, The Sapphire Group, Orange, Ohio, USA, Pathology Department, College of 0 Medicine, University of Vermont, Burlington, Vermont, USA, 4 Toxicology Excellence for Risk Assessment, Cincinnati, Ohio, USA, 1 5 6 / Naval Health Research Center, Wright Patterson Air Force Base, Ohio, USA, and The Sapphire Group, Dayton, Ohio, USA 0 1 / 1 1 n o 5 3 Abstract 1 . 1 1,3-Butadiene (BD) is a multisite carcinogen in laboratory rodents following lifetime exposure, with mice demon- 8 . 4 strating greater sensitivity than rats. In epidemiology studies of men in the styrene-butadiene rubber industry, 3 2 9. leukemia mortality is associated with butadiene exposure, and this association is most pronounced for high- 1 2 intensity BD exposures. Metabolism is an important determinant of BD carcinogenicity. BD is metabolized to sev- y b eral electrophilic intermediates, i