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advances in experimental research and in toxic and inhibitory polypeptides. Protein Sci. 3, 1833– Forum article, we provide a clear 1839 bioinformatics are made, predictive toxicity 3. Herzig, V. and King, G. (2015) The cystine knot is respon- picture of the current cloud-based testing might start to take a more promi- sible for the exceptional stability of the insecticidal spider NGS solutions and highlight what toxin v-hexatoxin-Hv1a. Toxins 7, 4366–4380 nent role in the weight-of-evidence 4. Zhu, S. et al. (2014) Experimental conversion of a defensin is still missing, along with future approach for novel proteins in food and into a neurotoxin: implications for origin of toxic function. Mol. Biol. Evol. 31, 546–559 challenges for the achievement feed, potentially reducing the number of 5. Marcy, E. et al. (1993) A novel gene containing a trinucle- of an ecosystem of biotechnology toxicity studies in animals. otide repeat that is expanded and unstable on Hunting- clouds. ton ’s disease chromosomes. The Huntington’s Disease Prospects Collaborative Research Group. Cell 72, 971–983 With the constant drive for innovation and 6. Landrum, E. and Wetzel, R. (2014) Biophysical underpin- nings of the repeat
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