Pathology of pituitary tumors英文电子书.pdf

Neurosurg Clin N Am 14 (2003) 25–39 Pathology of pituitary tumors Naoko Sanno, MD, PhDa,*, Akira Teramoto, MD, DMSca, b c R. Yoshiyuki Osamura, MD, PhD , Eva Horvath, PhD , Kalman Kovacs, MD, PhDc d , Ricardo V. Lloyd, MD, PhD , Bernd W. Scheithauer, MD, PhDe aDepartment of Neurosurgery, Nippon Medical School, 1-7-1 Nagayama Tama, Tokyo 206–8512, Japan bDepartment of Pathology, Tokai University School of Medicine, Isehara, Japan cDepartment of Pathology, St. Michael’s Hospital, University of Toronto, Toronto, Ontario, Canada dDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA eDepartment of Pathology, Mayo Clinic, Rochester, MN, USA Pituitary adenomas are benign neoplasms orig- pins (luteinizing hormone [LH] and follicle-stimu- inating in adenohypophysial cells. They represent lating hormone [FSH]) [5]. the most common neoplasm of the sellar region, Somatotrophs, or GH cells, constitute approx- comprising approximately 15% of all primary imately 50% of adenohypophysial cells. They are intracranial tumors [1–3]. Depending on the stud- located mainly in the lateral wings of the pars dis- ies of unselected adult autopsy material, their fre- talis; scattered somatotrophs can also be demon- quency as an incidental finding varies between strated in the median wedge. Somatotrophs are 5% and 20% [1,4]. spherical or oval medium-sized cells