Impaired myocardial autophagy linked to energy metabolism disorders英文电子书.pdf

Autophagy 8:6, 992–994; June 2012; G 2012 Landes Bioscience Impaired myocardial autophagy linked to energy metabolism disorders Zi-Lun Li1,2 and Lilach O. Lerman1,3,* 1Division of Nephrology and Hypertension; Mayo Clinic; Rochester, MN USA; 2Division of Vascular Surgery; the First Affiliated Hospital; Sun Yat-sen University; Guangzhou, China; 3Division of Cardiovascular Diseases; Mayo Clinic; Rochester, MN USA Autophagy represents an evolution- confirmed ex vivo. Although myocardial arily conserved catabolic mechanism perfusion increased in MetS, we found that promotes cell survival by releasing paradoxical hypoxia by BOLD-MRI. As energy substrates via degradation of myocardial oxygen consumption remained cellular constituents and by eliminating unchanged in MetS, we speculated that defective organelles under conditions of decreased myocardial oxygenation after stress, such as starvation and hypoxia. development of IR might be secondary The link between enhanced autophagy to impaired glucose utilization. Accord- © 2012 Landes Bioscience. and nutrient deprivation has been well ingly, SIRT1/sirtuin 1 was downregulated established. For example, chronic myo- in MetS, in association with decreased