探讨糖皮质激素辅助治疗中老年慢性阻塞性肺气肿的效果及对肺功能的影响.docVIP

精品论文 参考文献 探讨糖皮质激素辅助治疗中老年慢性阻塞性肺气肿的效果及对肺功能的影响 黑龙江省嫩江县伊拉哈镇中心卫生院 8161437 　　【摘 要】目的 研究分析抗生素与糖皮质激素联用治疗中老年慢性阻塞性肺气肿的效果及对肺功能的影响。方法 此次研究的对象是选取2012年1月～2015年8月我院92例中老年慢性阻塞性肺气肿患者，将其临床资料进行回顾性分析，并随机分为研究组和对照组，各46例。对照组采用单纯抗生素治疗，研究组在对照组的基础上联用糖皮质激素，使用SF-36量表评价生活质量，观察比较两组治疗总有效率、治疗前后肺功能指标变化情况及生活质量评分的差异。结果 研究组患者的治疗总有效率明显较对照组高（Plt;0.05）；治疗后研究组的肺活量、最大通气量较治疗前明显升高，优于对照组（Plt;0.05），研究组第一秒用力呼气容积占预计值百分比（FEV1%）、第一秒用力呼气容积与用力肺活量比值（FEV1/FVC%）较对照组显著下降（Plt;0.05）；研究组患者SF-36各维度评分均较对照组优（Plt;0.05）。结论 抗生素与糖皮质激素联用治疗中老年慢性阻塞性肺气肿患者效果确切，能有效缓解组织缺氧状态，改善肺功能，提高患者的生活质量，值得临床推广。 　【关键词】抗生素；糖皮质激素；慢性阻塞性肺气肿；肺功能 　　[Abstract] Objective To study the effect of combined use of antibiotics and glucocorticoid in the treatment of chronic obstructive pulmonary emphysema and its effect on lung function in elderly patients. The object of this research method is from January 2012 to August 2015 in our hospital 92 cases of elderly patients with chronic obstructive pulmonary emphysema，the retrospective analysis of the clinical data，were randomly divided into study group and control group，46 cases in each. The control group was treated with antibiotic therapy，on the basis of the research group in the control group with glucocorticoid，SF-36 scale was used to evaluate the quality of life，observe the treatment of the total efficiency of two groups，differences in the change of lung function and quality of life score before and after treatment. Results the patients in the study group，the total effective rate of treatment was significantly higher than the control group（Plt;0.05）；after treatment in the study group vitalcapacity，maximal ventilatory volume was significantly higher than that before treatment，better than the control group（Plt;0.05），the research group of the first second forced expiratory volume percentage of predicted value（FEV1%），forced expiratory volume in the first second and forced vital capacity the ratio（FEV1/FVC%）significantly decreased compared to the control group（Plt;0.05）；to study the dimensions of patients with SF-