探讨肿瘤坏死因子-a和白细胞介素-6在急性胰腺炎诊断及早期严重度评估的价值.docVIP

精品论文 参考文献 探讨肿瘤坏死因子-a和白细胞介素-6在急性胰腺炎诊断及早期严重度评估的价值 何晃养 (广东省新兴县人民医院急诊科 527400) 【中图分类号】R687【文献标识码】A【文章编号】1672-5085（2012）30-0223-02 【摘要】目的 探讨肿瘤坏死因子alpha;（TNF-alpha;）和白细胞介素6（IL-6）在急性胰腺炎（AP）患者中诊断及早期病情严重度评估中的价值。方法 选取81例AP患者，分为轻症急性胰腺炎（MAP）组57例和重症急性胰腺炎（SAP）组24例,对SAP组和MAP组在入院后1h、24h、2d、 3d、5d抽血测定TNF-alpha;和IL-6，并对结果进行分析。结果 SAP组和MAP组在入院后1h、24h、3d检测TNF-alpha;和IL-6的水平比较差异有统计学意义（Plt;0.05）。结论 血清TNF-alpha;和IL-6水平变化与AP的发生发展密切相关,可作为AP病情变化和程度判断的参考指标，对AP早期严重度具有良好的预测作用。 【关键词】急性胰腺炎 肿瘤坏死因子alpha; 白细胞介素6 Discussion Tumor necrosis factor-Alpha and Interleukin-6 in acute pancreatitis diagnosis and early severity appraisal HehuangYang Peoplersquo;shospital of Xinxing county，Xinxing Guangdong 527400, China 【Abstract】 Objective:To explore the value dynamic changes of serum levels of tumor necrosis factor-alpha;（TNF-alpha;） and interleukin-6（IL-6）and to determine their predictive value for severity and prognosis of acute pancreatitis（AP）。 Methods 81 patients with acute pancreatitis were divided into mild acute pancreatitis group（MAP,n=57） and severe acute pancreatitis group（SAP,n=24）,SAP and MAP Group at post ndash;admission 1h,24h,3d,dedicated TNF-a and IL-6,then analysed and contrasted the results。Results The chang of TNF-a and IL-6 levels at post-admission 1h、24h、2d、 3d、5d between SAP and MAP duringhospitalization in patients were statistically significant difference(Plt;0.05)。Conclusion Dynamic changes of the serum levels of TNF-alpha; and IL-6 are related to the occurance and development of acute pancreatitis,and the serum levels of TNF-alpha; and IL-6 on 3rd day may be a predictive index for severity and prognosis of acute pancreatitis. 【Key words】 Acute pancreatitis Tumor necrosis factor-alpha; Interleukin-6 急性胰腺炎（acute pancreatitis AP）是一种常见急腹症，是胰酶消化胰腺及其周围组织所引起的急性炎症，是一种以炎性细胞浸润、胰腺水肿、出血及坏死为特征的胰腺炎性疾病。AP在临床上可分为轻重两种，轻症急性胰腺炎(mild acute pancreatitis，MAP)占胰腺炎发病的80％，20％可进展为重症急性胰腺炎(severe acute pancreatitis，SAP)，不仅累及胰腺，而且影响肝、肺、肾等其他器官，病死率高达20％～