替吉奥与厄洛替尼治疗晚期非小细胞肺癌的疗效对比研究.docVIP

精品论文 参考文献 替吉奥与厄洛替尼治疗晚期非小细胞肺癌的疗效对比研究 陈姝 　　（河南省驻马店市中心医院药学部 河南 驻马店 463000） 　　【摘要】 目的：对比替吉奥与厄洛替尼治疗晚期非小细胞癌的疗效。方法：将82例患者分为替吉奥组和厄洛替尼组，分别接受替吉奥胶囊口服治疗与盐酸厄洛替尼片口服治疗。观察患者的近期疗效及不良反应。结果：两组患者的疾病缓解率，差异显著，具有统计学意义（P＜0.05）；疾病控制率相比差异不显著，无统计学意义（P＞0.05）。结论：（1）替吉奥与厄洛替尼治疗晚期非小细胞肺癌均可在一定程度上缓解疾病、控制疾病，并提高无疾病进展期与总生存期。（2）替吉奥治疗晚期非小细胞肺癌的近期疗效及安全性均优于厄洛替尼，但远期疗效与厄洛替尼相比稍差。 　　【关键词】替吉奥；厄洛替尼；晚期非小细胞肺癌；疗效 　　【中图分类号】R730.5 【文献标识码】A 【文章编号】2095-1752（2015）28-0029-02 　　For sergio and it on behalf of, the curative effect of treatment of advanced non-small cell lung cancer 　　Chen Shu. Centor Hospital of Zhumadian City, Henan Province, Zhumadian 463000, China 　　【Abstract】 Objective Contrast for gonow with it for the curative effect of treatment of advanced non-small cell carcinoma. Methods Will gonow for 82 patients were divided into groups and for it, respectively for gonow capsule oral treatment with hydrochloric acid it for his oral treatment. The recent curative effect and adverse reactions were observed. ResultsTwo groups of patients with the disease remission rate, significant difference, statistically significant (P lt; 0.05); Disease control rates compared with no significant difference, no statistical significance (P gt; 0.05). Conclusions (1) for gonow with it for his treatment of advanced non-small cell lung cancer are to some extent alleviate disease, disease control, and improve without disease progression and overall survival. Gonow for (2) the treatment of advanced non-small cell lung cancer in the near future curative effect and safety were superior to, for it, but the long-term curative effect compared with, for it is a bit poor. 　　【Key words】On behalf of gonow; For it; Advanced non-small cell lung cancer; The curative effect 　　肺癌是当前全世界最为易见的一类恶性肿瘤，已经成为全世界恶性肿瘤死亡的重要原因之一，对人类的身体健康和生命质量造成了严重的威胁，更为严峻的是，大部分国家的肺癌发病率仍呈上升趋势，尤其是发达国家与发展中国家[1]。肺癌主要包括非小细胞肺癌（non-small cell lung cancer, NSCLC）与小细胞肺癌这两大类，其中，NSCLC大概占肺癌总发病率的80%[2]。当今医学领域学者及研究人员对厄洛替尼和替吉奥治疗晚期NSCLC分别进行了一些相关研究，并显示出它们对