替吉奥联合草酸铂对比替吉奥治疗老年晚期胃癌临床观察.docVIP

精品论文 参考文献 替吉奥联合草酸铂对比替吉奥治疗老年晚期胃癌临床观察 蒋晓东１　徐浩１　余超　葛坤元１　印鑫１　闵科２ １．江苏大学附属宜兴医院介入康复科　江苏　宜兴　２１４２００;２．江苏大学附属宜兴医院肿瘤科　江苏　宜兴　２１４２００ 作者简介:蒋晓东(１９７３－),男,江苏宜兴人,本科,副主任医师,主要从事肿瘤化疗及肿瘤介入治疗研究. 通讯作者:闵科(１９８１－),女,江苏宜兴人,本科,主治医师,主要从事肿瘤内科治疗工作. 　　【摘要】　目的　观察替吉奥联合草酸铂对比替吉奥单药治疗老年晚期胃癌的临床效果.方法　回顾分析我院收治的８６例老年晚期胃癌患者,按照化疗方案分为两组,A组化疗方案为单药替吉奥口服,B组化疗方案为替吉奥联合草酸铂,治疗４周期后观察两组患者的一般情况、化疗副反应、近期有效率,并随访两组的一年生存率及总生存时间.结果　???周期化疗后,A组KPS评分改善率与B组比较无统计学意义(P＞０．０５);A 组近期有效率较B组低(３７．１％,６７．５％),比较有明显统计学差异(P＜０．０１);治疗过程中,A组发生Ⅱ~Ⅳ度白细胞、血小板下降及外周神经毒性人数较B组少,比较有统计学意义(P＜０．０５);两组一年生存率比较无统计学意义(P＞０．０５);Kaplan－Meier生存曲线提示B组较A 组无明显生存优势(P＞０．０５).结论　替吉奥联合草酸铂较单药替吉奥治疗老年晚期胃癌具有更高的近期有效率,但增加了化疗副反应,且并不能提高患者的一年生存率及总生存时间. 【关键词】　老年晚期;胃癌;替吉奥;草酸铂;总生存时间【Abstract】Objective　TocomparetheclinicalefficacyofS１combinedwithoxaliplatinwithS１aloneintreatingeldlypatientswithadvancedgastriccancers．MethＧods　Totally８６eldlypatientswithadvancedgastriccancerswereretrospectivelyanalyzed．Casesweredividedintotwogroupsbyregimens．GroupAwastreatedwithS１alone,whilegroupBgivenS１combinedwithoxaliplatin．After４cycles,patientsrsquo;performancestatus,adverseevents,responserate,following－uponeyearsurＧvivaltimeandoverallsurvivalwereevaluated．Results　After４cyclesofchemotherapy,KPSimprovementhadnostatisticalsignificancebetweentwogroups(P＞０．０５)．ResponserateingroupAwaslowerthanthatingroupB(３７．１％,６７．５％),whichhadstatisticaldifference(P＜０．０１)．ThenumbersofⅡ~Ⅳleukocyte,plateＧletdeclineandperipheralnervetoxicityingroupAwerefewerthaningroupB,alsohadstatisticalsignificance(P＜０．０５)．Theoneyearsurvivalratehadnosignificantdifferencebetweentwogroups(P＞０．０５)．Kaplan－MeiersurvivalcurvedemonstratedthatgroupBhadnobettersurvivaladvantagethangroupA(P＞０．０５)．ConcluＧsion　S１combinedwithoxaliplatinhadhigherresponseratecomparedwithS１aloneintreatingeldlypatientswithadvancedgastriccancers,however,sideeffectsinＧcreased,andcouldnotimprovetheoneyearsurvivalrateandoverallsurvival．【Keywords】advancedgastriccancer;eldly;S１;oxaliplatin;overallsurvival 【中图分类号】R７３０ 【文献标识码】B 　　【文章编号】１００８－６３１５(２０１５)１２－０１１９－０１　　 　　我国是胃癌的高发地区,发